Troubleshooting "Network Unreachable" for a particular application...all others work fine.

sorghumking

Ars Scholae Palatinae
985
I'm running Windows 10 Pro. One application is unable to connect to the internet: "Network unreachable" error. All other applications work properly. AFAICT the problem application isn't being blocked by Windows Firewall, etc. Reinstalling the problem app makes no difference. Using a different network (e.g. phone's hotspot) makes no difference.

Strangely (to me and my very limited understanding of VMs and networking), in a Win10 VM running in Hyper-V on this machine, the same application works properly!

Seems like it has to be an issue with with my Windows configuration. Are there likely suspects I've missed? Any troubleshooting advice or other wisdom would be greatly appreciated; I'm absolutely stumped. Thanks!